The 2025 MLB season is shaping up to be one of the most exciting in recent memory. With fresh talent emerging, long-standing rivalries heating up, and unexpected storylines developing, fans have plenty to look forward to. As someone who’s followed baseball for years, I always circle a few key games on my calendar. Whether it’s a high-stakes rivalry, a potential playoff preview, or a clash between MVP contenders, these are the matchups you won’t want to miss. Here are the top 10 must-watch MLB games of the 2025 season.

• Opening Day: New York Yankees vs. Boston Red Sox (March 27)

It wouldn’t be baseball season without the Yankees and Red Sox renewing their historic rivalry. Opening Day at Fenway Park will set the tone for both teams, as they aim to start the season with a statement win. With Aaron Judge and Rafael Devers leading their respective lineups, expect fireworks right out of the gate.

• Los Angeles Dodgers vs. Atlanta Braves (April 15)

This is a showdown between two National League powerhouses that could easily be an early NLCS preview. The Braves’ high-powered offense, led by Ronald Acuña Jr., will test the Dodgers’ revamped pitching staff. With both teams eyeing a deep postseason run, this game could have long-term implications.

• Houston Astros vs. Texas Rangers (May 10)

The battle for Texas has never been more intense. The reigning World Series champion Rangers are looking to defend their title, while the Astros remain a perennial contender. This game will be a measuring stick for both teams, and Minute Maid Park will be buzzing with energy.

• Chicago Cubs vs. St. Louis Cardinals (June 1)

One of the most storied rivalries in baseball takes center stage at Wrigley Field. Both teams have made key offseason moves, and with young stars emerging, this game could be a glimpse into the future of the NL Central. Expect a playoff-like atmosphere, even in June.

• Baltimore Orioles vs. San Francisco Giants (June 18)

Two rising teams with playoff aspirations meet in an interleague clash that could be one of the season’s most intriguing matchups. The Orioles’ young core, featuring Adley Rutschman and Gunnar Henderson, will face off against the Giants’ new-look roster. If you’re a fan of detailed analytics, check out the Baltimore Orioles vs. San Francisco Giants match player stats to see how these squads stack up.

• All-Star Game: National League vs. American League (July 15)

The midsummer classic is always a must-watch, but 2025’s edition in Seattle promises to be special. With a mix of seasoned superstars and first-time All-Stars, this game will showcase the best talent in baseball. Plus, with the new format changes, expect more excitement than ever before.

• Philadelphia Phillies vs. San Diego Padres (August 2)

Both teams have World Series ambitions, making this late-season clash a crucial test. Bryce Harper and Juan Soto facing off is always a spectacle, but the real intrigue lies in how these teams’ pitching rotations will hold up in a high-pressure environment.

• New York Mets vs. Los Angeles Angels (August 20)

Shohei Ohtani’s departure from the Angels left a void, but the Mets are now benefiting from his two-way excellence. This game not only marks a return to Anaheim for Ohtani, but it also showcases two teams desperate to make a playoff push. Will the Angels regret letting him go? We’ll find out.

• Toronto Blue Jays vs. Seattle Mariners (September 5)

Both teams are expected to battle for Wild Card spots, making this September showdown crucial. With Vladimir Guerrero Jr. and Julio Rodríguez leading their squads, this game could have massive postseason implications. Expect every pitch to matter.

• Final Regular Season Game: Milwaukee Brewers vs. Cincinnati Reds (September 29)

The last game of the season could determine a division title or Wild Card berth, and both the Brewers and Reds are expected to be in the mix. There’s nothing like the drama of a final-day showdown where every at-bat could change the course of the playoffs.

Final Thoughts

The 2025 MLB season is loaded with can’t-miss games, and these ten matchups are just the beginning. Whether you’re a die-hard fan or a casual viewer, there will be no shortage of action, drama, and unforgettable moments. Mark your calendars, set your reminders, and get ready for an incredible year of baseball.